Radioimmunoassay for Plasma Dehydroepiandrosterone (DHEA) —Dexamethasone Suppressibility of Plasma DHEA—
نویسندگان
چکیده
منابع مشابه
DHEA: dehydroepiandrosterone.
Dehydroepiandrosterone (DHEA) and its active metabolite, DHEA sulfate (DHEAS), are endogenous hormones synthesized and excreted primarily by the zona reticularis of the adrenal cortex in response to adrenocorticotropic hormone. The exact mechanism of action and clinical role, if any, of DHEA and DHEAS remain unclear. Epidemiological data indicate an inverse relationship between serum DHEA and D...
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Hypercortisolaemia is a feature of many severe psychiatric illnesses and has been suggested to be both a causal and exacerbating factor of clinical symptoms and neurocognitive impairment. The adrenal steroid dehydroepiandrosterone (DHEA) has antiglucocorticoid properties that may have regulatory effects on glucocorticoid action in the brain. However, there is a paucity of data on these steroids...
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Until recently there has been no adequate clinical method for precisely measuring dexamethasone in blood. Studies of therapeutic dexamethasone concentrations and of its metabolism in plasma have relied on the use of radioactive dexamethasone (1-3). We report here an immunoassay in which antisera obtained from rabbits immunized with a conjugate of dexamethasone and bovine serum albumin (BSA) are...
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Neurosteroid dehydropiandrosterone (DHEA) and its sulphate (DHEAS) are reported to have modulatory effects on neuronal excitabillity and synaptic plasticity. DHEA and DHEAS are synthesized in central and peripheral nervous system from cholesterol or steroidal precursors imported from peripheral sources. There is accumulating evidence that alterations in DHEA(S) levels may be involved in the pat...
متن کاملThe association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women.
Concentrations of adrenal androgens are positively associated with postmenopausal breast cancer risk; however, results in premenopausal women are conflicting. Therefore, we conducted a prospective nested case-control study within the Nurses' Health Study II cohort to examine the relationship of DHEA and DHEA sulfate (DHEAS) with breast cancer risk in predominantly premenopausal women. Blood sam...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1978
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.27.6_338